The scale-up of processes from bench to commercial scale is challenging because of uncertainties about the physiochemical environment experienced by the cells at large scale.

Process modeling tools can be useful in facilitating the scale-up and technology transfer of microbial and mammalian processes by ensuring that the process requirements can be met by the facility capabilities.

Antibiotics are among the most frequently prescribed biopharmaceuticals drugs in modern medicine. Antibiotics cure disease by killing or injuring bacteria.

There are ranges of antibiotics available in market.

Streptomycin and various other antibiotics are produced by using antibiotics producing strain inoculated into a medium to establish a culture with a high mycelial biomass for introduction into an Inoculum tank, with subsequent use of the mycelial Inoculum to initiate the fermentation process in the production tank.

After the process is complete, mycelium is separated from the broth by filtration and the antibiotic recovered. In one method of recovery and purification, streptomycin is adsorbed onto activated charcoal and eluted with acid alcohol. It is then precipitated with acetone and further purified by use of column chromatography.

Neela's contribution to the vaccine industry is becoming more and more prominent.

Various solutions for the plant lie in equipments and accessories with the following functions:
1. Media Prepration
2. Media Hold
3. Media Sterilization
4. Broth Hold
5. Adsorption
6. Elution
7. Preception
8. Purification

Every component selected critically passes a thorough selection process with design inputs from users.

Process Cycles
From Precision temperature cycles to CIP / SIP of equipments & accessories/ Media charging / inoculation; process equipments designed by Neela facilitates the needs of the process.

Accessories
From accessories for mixing to sterile sampling / venting / gas feed / transfer / sterile dip tubes / sparging the vessels come with a variety of combinations to suit the process needs of the user.

Instrumentation
Comprehensive instrumentation for measurement of Temperature/ pH/ Level / Conductivity/ Dissolved Oxygen/ CO₂/ Pressure could be a part of the vessel package depending upon the process needs of the user.

Safety Devices
Appropriate design of the vessel heat transfer jacket to ensure operator safety apart from a well designed Safety equipment like safety valves/ rupture discs/ vacuum breaker/ etc. makes it safe for the users while maintaining the clean-ability/ sterility.

Automation
Depending on the scope and requirement of the users, these equipments can be unit controlled or loop controlled with a multiple of equipments together. From a simple electrical Relay based control to complex DCS control, the equipments can be designed to meet any Automation needs of the user. Adequate hot swappable redundancy can be defined from the Network alone to Central Processor.