Monoclonal antibodies (MABs), one of the most significant classes of new drugs to emerge from the biotech industry, were invented in the UK.

MABs are very attractive drugs, offering effective and efficacious treatments that are often superior to small molecule drugs.
Monoclonal antibodies are designed to demonstrate efficacy with low toxicity and are expected to reduce overall treatment and hospitalization costs associated with the side effects and opportunistic infections, which can result from chemotherapy or radiation therapy

Unlike chemotherapy and radiotherapy, which act in a less specific way, the aim of monoclonal antibody treatment is to destroy cancerous cells in a targeted way and to leave other types of cells unharmed.

1. In-vitro process (tissue culture)
The simplest method for producing the monoclonal antibodies in-vitro is to grow the hybridoma cultures in batches and purify it from the tissue culture medium

2. In-vivo process

• Immunisation of mice for generating hybridoma cells.
• Screening of mouse for antibody production.
• Preparation of myeloma cells.
• Fusion of mylemocells with immune spleen cells.
• Cloning of hybridoma cell.

In-vitro, that is, in culture vessels. The yield runs from 10-60g/mL. In-vivo; ie, growing in mice. Here, the antibody concentration in the serum and other body fluids can reach 1-10 mg/mL.

Before production of antibodies by either method, hybrid cells that will produce the antibodies are generated.

Neela's contribution to the vaccine industry is becoming more and more prominent.

Various solutions for the plant lie in equipments and accessories with the following functions.
1. Media preparation vessel
2. Media hold
3. Purification vessel
4. Storage vessel

Every component selected critically passes a thorough selection process with design inputs from users.

Process Cycles
From Precision temperature cycles to CIP / SIP of equipments & accessories/ Media charging / inoculation; process equipments designed by Neela facilitates the needs of the process.

Accessories
From accessories for mixing to sterile sampling / venting / gas feed / transfer / sterile dip tubes / sparging the vessels come with a variety of combinations to suit the process needs of the user.

Instrumentation
Comprehensive instrumentation for measurement of Temperature/ pH/ Level / Conductivity/ Dissolved Oxygen/ CO₂/ Pressure could be a part of the vessel package depending upon the process needs of the user.

Safety Devices
Appropriate design of the vessel heat transfer jacket to ensure operator safety apart from a well designed Safety equipment like safety valves/ rupture discs/ vacuum breaker/ etc. makes it safe for the users while maintaining the clean-ability/ sterility.

Automation
Depending on the scope and requirement of the users, these equipments can be unit controlled or loop controlled with a multiple of equipments together. From a simple electrical Relay based control to complex DCS control, the equipments can be designed to meet any Automation needs of the user. Adequate hot swappable redundancy can be defined from the Network alone to Central Processor.